new release: B.C. is taking the right approach to managing cancer of uterus and ovary (dual early stage primaries) Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Tuesday, February 09, 2016

new release: B.C. is taking the right approach to managing cancer of uterus and ovary (dual early stage primaries)



BC Cancer Agency


....The scientists explain the apparent paradox of the same cancer appearing simultaneously as two independent early-stage tumours on two different organs by invoking a novel process they call “pseudo-metastasis”. They propose that the process is distinct from usual metastasis in that the cancer likely spreads through the fallopian tube, not the blood stream, and that the host organs (ovary and uterus) provide a unique environment where these cancers are initially constrained.     

“Pseudo-metastasis is still something of a mystery,” says Dr. Michael Anglesio, lead author and Research Associate in the department of Molecular Oncology at the BC Cancer Agency. “Whether the initial event takes place in the ovary or the endometrium, and what keeps cells temporarily restricted to these special organs without metastasizing to the rest of the body, are things that we are now researching.”.....
 
.....Meanwhile, a highly complementary study from Memorial Sloan Kettering Cancer Center (MSKCC), published in the same issue of JNCI, is giving both research teams overwhelming confidence in their findings. 

“We are delighted that the findings of our studies are in agreement,” says Dr. Britta Weigelt, Assistant Member of the Department of Pathology at MSKCC. “Together, these studies have resulted in a paradigm shift in the way SEO cancers are perceived. By bringing together pathology and genetics, we have solved a long standing biological question and clinical dilemma.”....

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