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BC Cancer Agency
....The scientists explain the apparent
paradox of the same cancer appearing simultaneously as two independent
early-stage tumours on two different organs by invoking a novel process
they call “pseudo-metastasis”. They propose that the process is distinct
from usual metastasis in that the cancer likely spreads through the
fallopian tube, not the blood stream, and that the host organs (ovary
and uterus) provide a unique environment where these cancers are
initially constrained.
“Pseudo-metastasis
is still something of a mystery,” says Dr. Michael Anglesio, lead author
and Research Associate in the department of Molecular Oncology at the
BC Cancer Agency. “Whether the initial event takes place in the ovary or
the endometrium, and what keeps cells temporarily restricted to these
special organs without metastasizing to the rest of the body, are things
that we are now researching.”.....
.....Meanwhile, a highly complementary
study from Memorial Sloan Kettering Cancer Center (MSKCC), published in
the same issue of JNCI, is giving both research teams overwhelming
confidence in their findings.
“We are
delighted that the findings of our studies are in agreement,” says Dr.
Britta Weigelt, Assistant Member of the Department of Pathology at
MSKCC. “Together, these studies have resulted in a paradigm shift in the
way SEO cancers are perceived. By bringing together pathology and
genetics, we have solved a long standing biological question and
clinical dilemma.”....
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