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open access:
Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 | Breast Cancer Research | Full Text
The lifetime risk of developing MBC has been estimated to be in the range of 1–5 % for BRCA1 and 5–10 % for BRCA2 mutation carriers, compared with a risk of 0.1 % in the general population [6–9].
Conclusions
On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs (female), and we identified a specific BRCA2-associated
MBC phenotype characterised by a variable suggesting greater biological
aggressiveness (i.e., high histologic grade). These findings could lead
to the development of gender-specific risk prediction models and guide
clinical strategies appropriate for MBC management.
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