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abstract
BACKGROUND
With
prior reports indicating a lack of progress in survival improvement in
older adolescents and young adults (AYAs) aged 15 to 39 years with
cancer compared with both younger and older patients with cancer, the
current analysis provides an update of survival trends of cancers among
AYAs, children, and older adults.
METHODS
Data
from the National Cancer Institute Surveillance, Epidemiology, and End
Results database for 13 regions were used to ascertain survival trends
of the 34 most frequent cancers diagnosed in AYAs compared with children
and older adults.
RESULTS
As
of 2002 through 2006, the 5-year relative survival rate for all
invasive cancers in AYAs was 82.5% (standard error, 0.2%). In AYAs, 14
cancers demonstrated evidence of a statistically significant improvement
in their 5-year relative survival since 1992. Survival improved less in
AYAs than in children for acute myeloid leukemia and medulloblastoma.
Fourteen cancers had survival improvements that were found to be less in
AYAs compared with older adults, including hepatic carcinoma, acute
myeloid leukemia, high-grade astrocytoma, acute lymphocytic leukemia,
pancreatic carcinoma, low-grade astrocytoma, gastric carcinoma, renal
carcinoma, cancer of the oral cavity and pharynx, Hodgkin lymphoma,
ovarian cancer, fibromatous sarcoma, other soft tissue sarcoma, and
thyroid carcinoma.
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