abstract
Published Online: July 14, 2015
OBJECTIVE:
Ovarian
preservation is an option for some premenopausal patients with early
stage endometrial cancer. Studies have shown that ovarian preservation
in selected patients does not negatively impact survival outcomes. The
objective of this study is to determine the frequency and
characteristics of ovarian involvement when endometrial cancer is
clinically confined to the uterus.
METHODS:
Patients
with endometrioid adenocarcinoma of uterus treated at our institution
between 2000 and 2013 were identified. Patients with ovarian metastasis
or synchronous primary ovarian cancer were included. Patients were
excluded if there was gross extrapelvic disease on examination or
imaging.
RESULTS:
Seven
hundred and fifty-nine patients were found to have endometrial cancer
with the disease confined to the pelvis (stages I, II, and III).
Fifteen
patients (2%) had ovarian metastasis. Twenty-three patients (3%) had
synchronous uterine and ovarian cancer. Most ovarian lesions (32 out of
38) were either enlarged or had abnormal appearing surface involvement.
Six patients had
microscopic ovarian involvement, accounting for 0.8% of
the endometrial cancer patients with pelvis-confined disease. All of
the patients were greater than 50 years of age.
For those patients with
microscopic ovarian metastasis, all had FIGO grade 3 disease, deep
myometrial invasion, and extrauterine involvement of either cervix or
lymph nodes.
CONCLUSIONS:
Microscopic
ovarian involvement occurred in 0.8% of patients with endometrial
cancer. For premenopausal patients with endometrial cancer, normal
appearing ovaries may be considered for preservation in the absence of
extrauterine spread, grade 3 disease and deep myometrial invasion.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.