|
|
|
|
|
|
|
|
|
|
science news
....... Recently, Dr. Shepherds' lab discovered that the spheroids activate a 'stress signal', and the major molecule controlling this signal is called LKB1. "Previous studies stated that LKB1 was a tumour suppressor in ovarian cancer, meaning that tumour cells need to get rid of LKB1 to cause cancer," says Dr. Shepherd "but our work is in direct conflict with these studies, because we definitively show that ovarian cancer cells still have LKB1 and that this molecule allows ovarian cancer spheroids to change their metabolism, promote tumour cell survival and make them more resistant to chemotherapy."
By refuting these previous studies, Dr. Shepherd has uncovered a new target for future therapy. "There are currently no therapies or drugs that target LKB1," states Dr. Shepherd. "Based on these findings our lab is exploring several different strategies to understand and target LKB1 and its related molecules in ovarian cancer spheroids, and developing the essential pre-clinical models to see if this can be translated to ovarian cancer patients."
Story Source:
The above post is reprinted from materials provided by Lawson Health Research Institute.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.