Impact of statins on risk and survival of ovarian cancer Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Friday, July 24, 2015

Impact of statins on risk and survival of ovarian cancer



KoreaMed Synapse

 J Gynecol Oncol. 2015 Jul;26(3):240-241. English.
Published online July 08, 2015.  http://dx.doi.org/10.3802/jgo.2015.26.3.240
Copyright © 2015. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology

 Table 1. Summary of the evidence regarding impact of statin therapy on risk and survival of ovarian cancer

.....When findings of five studies [8, 10, 11, 12, 13] were pooled in a meta-analysis conducted by Liu et al. [14], a significant 21% risk reduction was seen (relative risk [RR], 0.79; 95% confidence interval [CI], 0.64 to 0.98). The RR reduction was found to be 52% when long term statin usage was considered (RR, 0.48; 95% CI, 0.28 to 0.80). In conclusion, we suggest that statins impact on ovarian cancer warrants further investigation with larger randomized controlled trials as observational studies are subject to bias and may lead to false slight benefits. Effect of statins with respect to different histological subtypes also need to be further studied.

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