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open access (pdf)
Granulosa cell tumors are representative of estrogenic ovarian
tumors, and some Sertoli-stromal cell tumors are also estrogenic. The
exact cells that are responsible for estrogenesis, however, have yet to
be identified. In the present study, 25 sex cord-stromal tumors (20
granulosa cell tumors, 4 Sertoli-Leydig cell tumors, and a Sertoli cell
tumor) were immunohistochemically examined for expression of P450
aromatase, which is critical for estrogenesis. All of the tumors had
been evaluated regarding their estrogenic function, including
contemporaneous endometrial hyperplasia and/or elevation of serum
estradiol. Eleven of 14 estrogenic granulosa cell tumors showed sparse
or aggregated immunoreactivity for aromatase, whereas 5 of 6
nonestrogenic tumors did not. Aromatase was selectively expressed by
plump granulosa cells with eosinophilic or vacuolated cytoplasm,
resembling luteinized granulosa cells. Such a localization of aromatase
is analogous to that in normal ovaries. Aromatase expression in primary
tumors was recapitulated by recurrent tumors. In Sertoli-stromal cell
tumors, either undifferentiated plump cells or well-differentiated
Sertoli cells expressed aromatase. In conclusion, the expression of P450
aromatase corresponds to specific cell morphology in sex cord-stromal
tumors, including recurrent tumors. Aromatase status in granulosa cell
tumors provides helpful information on whether serum estradiol could be a
marker for recurrence.
This is an open-access article distributed under the
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License 4.0 (CCBY-NC-ND), where it is permissible to download and share
the work provided it is properly cited. The work cannot be changed in
any way or used commercially.
http://creativecommons.org/licenses/by-nc-nd/4.0/
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