Identification of rare germline copy number variations over-represented in five human cancer types

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".... Results  We explored the germline CNVs (copy number variations) in five cancer cohorts from the Cancer Genome Atlas (TCGA) consisting of 351 brain, 336 breast, 342 colorectal, 370 renal, and 314 ovarian cancers, genotyped on Affymetrix SNP6.0 arrays.....

 ......Many of these loci are new and in some cases are associated with a substantial increase in disease risk......