Breast Cancer Patients Referred for Genetic Testing Likely to Have Mutations Other Than BRCA1/2 Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Thursday, January 22, 2015

Breast Cancer Patients Referred for Genetic Testing Likely to Have Mutations Other Than BRCA1/2



Mutations 


Results revealed that 1608 (9.5%) of females and 32 (16.2%) of males were positive for at least one deleterious or suspected deleterious mutation. Interestingly, among these mutations:
  • 48.9% were detected in the Hereditary Breast and Ovarian Cancer (HBOC) genes BRCA1 and BRCA2.
  • 42.1% were detected in other genes associated with breast cancer.
  • 6.6% were detected in Lynch syndrome genes (MLH1, MSH2, MSH6, PMS2, EPCAM).
  • 2.3% were detected in other genes not associated with breast cancer (APC, MUTYH, RAD51D, CDKN2A, SMAD4).
- See more at: http://www.targetedonc.com/conference/sabcs-2014/Breast-Cancer-Patients-Referred-for-Genetic-Testing-Likely-to-Have-Mutations-Other-Than-BRCA12#sthash.qnb07U8O.dpuf
Results revealed that 1608 (9.5%) of females and 32 (16.2%) of males were positive for at least one deleterious or suspected deleterious mutation. Interestingly, among these mutations:
  • 48.9% were detected in the Hereditary Breast and Ovarian Cancer (HBOC) genes BRCA1 and BRCA2.
  • 42.1% were detected in other genes associated with breast cancer.
  • 6.6% were detected in Lynch syndrome genes (MLH1, MSH2, MSH6, PMS2, EPCAM).
  • 2.3% were detected in other genes not associated with breast cancer (APC, MUTYH, RAD51D, CDKN2A, SMAD4).
- See more at: http://www.targetedonc.com/conference/sabcs-2014/Breast-Cancer-Patients-Referred-for-Genetic-Testing-Likely-to-Have-Mutations-Other-Than-BRCA12#sthash.qnb07U8O.dpuf

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