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Mutations
Results
revealed that 1608 (9.5%) of females and 32 (16.2%) of males were
positive for at least one deleterious or suspected deleterious mutation.
Interestingly, among these mutations:
- 48.9% were detected in the Hereditary Breast and Ovarian Cancer (HBOC) genes BRCA1 and BRCA2.
- 42.1% were detected in other genes associated with breast cancer.
- 6.6% were detected in Lynch syndrome genes (MLH1, MSH2, MSH6, PMS2, EPCAM).
- 2.3% were detected in other genes not associated with breast cancer (APC, MUTYH, RAD51D, CDKN2A, SMAD4).
Results
revealed that 1608 (9.5%) of females and 32 (16.2%) of males were
positive for at least one deleterious or suspected deleterious mutation.
Interestingly, among these mutations:
- 48.9% were detected in the Hereditary Breast and Ovarian Cancer (HBOC) genes BRCA1 and BRCA2.
- 42.1% were detected in other genes associated with breast cancer.
- 6.6% were detected in Lynch syndrome genes (MLH1, MSH2, MSH6, PMS2, EPCAM).
- 2.3% were detected in other genes not associated with breast cancer (APC, MUTYH, RAD51D, CDKN2A, SMAD4).
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