Hereditary Cancer-Associated Mutations in Women Diagnosed with Two Primary Cancers: An Opportunity to Identify Hereditary Cancer Syndromes after the First Cancer Diagnosis

FullText    Myriad Genetic Laboratories, Inc., Salt Lake City, Utah, USA 


 Results: Among women with both breast and ovarian cancer, 22.4% (2,237/9,982) had a BRCA1 or BRCA2 mutation. Among women with both colorectal and ovarian cancer, 28.1% (264/941) had a mutation associated with LS. In 66.6% of BRCA1 or BRCA2 mutation carriers and in 58.3% of LS mutation carriers, >5 years passed between the cancer diagnoses.......

 Table 2. Interval between the first and the second cancer diagnosis in patients with HBOC



 Table 4. Interval between first and second cancer diagnoses in patients with LS